Copper-Catalyzed Cascade Double C3-Indolations of 3‑Diazoindolin-2-imines with Indoles: Convenient Access to 3,3-Diaryl-2-iminoindoles

Symmetrical 3,3-diaryl-2-iminoindoles were prepared from 3-diazoindolin-2-imines and indoles via a copper-catalyzed cascade arylation/dehydrogenative cross-coupling process. By controlling the molar ratio of reactants and the operation procedure, 3-aryl-2-aminoindoles and asymmetrical 3,3-diaryl-2-iminoindoles could be approached.

以3-重氮吲哚-2-亚胺（3-diazoindolin-2-imines）与吲哚（indoles）为原料，通过铜催化级联芳基化/脱氢交叉偶联反应，可制备得到对称3,3-二芳基-2-亚氨基吲哚（3,3-diaryl-2-iminoindoles）。通过调控反应物摩尔比与操作流程，还可合成得到3-芳基-2-氨基吲哚（3-aryl-2-aminoindoles）与不对称3,3-二芳基-2-亚氨基吲哚。