Kinase Genotyping of Gastro Intestinal Stomach Tumors (GISTs) From Patients Enrolled in Pfizer A6181112 Phase IIIb Trial

The purpose of this study is to determine the genetic makeup of gastro intestinal stomach tumors (GISTs) from patients enrolled in the A6181112 phase IIIb trial. Tumor samples will be screened for mutations and this information will be used to determine whether the progression-free survival of patients being treated with the cancer medication sunitinib is related to the underlying genotype of their GIST.

本研究旨在明确A6181112 IIIb期临床试验入组患者的胃肠道间质瘤（GISTs）的基因组成。研究将对肿瘤样本进行突变筛查，并利用所得筛查信息，探究接受癌症药物舒尼替尼治疗的患者的无进展生存期是否与其胃肠道间质瘤的潜在基因型存在关联。