Data set related to the project RF-2016-02364864 "Exploiting BPIFB4 and its longevity-associated variant in the fight against cardiovascular diseases"

Data set related to the project RF-2016-02364864 "Exploiting BPIFB4 and its longevity-associated variant in the fight against cardiovascular diseases" Background: Maintaining the homeostasis of the vascular system is the prerequisite for delaying cardiovascular diseases (CVDs). In addition to endothelial function, circulating endothelial progenitors (EPCs) number predicts cardiovascular health. We recently discovered a Longevity-Associated Variant of BPIFB4 that modulates endothelial response and EPC mobilization. Of note, serum BPIFB4 levels classify healthy centenarians. Hypothesis: BPIFB4 is a new determinant of cardiovascular health. Specific Aim 1: Demonstrate the association of circulating serum BPIFB4 with atherosclerotic cardiovascular diseases in humans. Verify the additive value of BPIFB4 levels and EPC number in disease prediction. Specific Aim 2: Prove the potential of delivering BPIFB4 recombinant protein in rescuing atherosclerosis in mice. Specific Aim 3: Dissect the molecular mechanisms associated with BPIFB4 activity in EPCs and vascular cells本数据集关联项目RF-2016-02364864“探索BPIFB4及其长寿相关变异体以对抗心血管疾病”。背景：维持血管系统稳态是延缓心血管疾病（cardiovascular diseases, CVDs）的必要前提。除内皮功能外，循环内皮祖细胞（endothelial progenitors, EPCs）的数量可预测心血管健康状态。本研究团队近期发现BPIFB4的一种长寿相关变异体，该变异体可调控内皮应答与内皮祖细胞的动员过程。值得注意的是，血清BPIFB4水平可区分健康百岁老人。研究假说：BPIFB4是心血管健康的新型决定因子。具体研究目标1：证实循环血清BPIFB4水平与人类动脉粥样硬化性心血管疾病的关联，并验证BPIFB4水平与内皮祖细胞数量在疾病预测中的附加价值。具体研究目标2：证实递送BPIFB4重组蛋白可挽救小鼠动脉粥样硬化的潜力。具体研究目标3：解析BPIFB4在内皮祖细胞与血管细胞中发挥活性的分子机制。