Transcriptome sequencing data of tier 1 mutations.

The expression of tier1 genes was estimated using Transcriptome sequencing data. For each gene, identified by a unique Ensembl identity (ID) code, the estimation of expression was calculated using Cufflinks and reported as FPKM (number of fragments per kilobase of exon per million fragments mapped: Cufflinks FPKM). Each FPKM value was calculated with a confidence interval ranging between Low CI and High CI values. Mutated allele expression summarizes the percentage of mutated reads covering the mutation site.

Tier1基因的表达量通过转录组测序（Transcriptome sequencing）数据进行估算。对于每个通过唯一Ensembl基因标识符（Ensembl identity (ID) code）标识的基因，其表达量估算值采用Cufflinks工具计算，并以FPKM（每百万比对片段的外显子每千碱基片段数：Cufflinks FPKM）的形式进行报告。每个FPKM值均配有介于低置信限（Low CI）与高置信限（High CI）之间的置信区间。突变等位基因表达量指覆盖突变位点的突变读段（reads）所占的百分比。