A promising clinical treatment for EGFRI-induced rash by targeting the early pathological alteration revealed by transcriptome analysis

In order to investigate the early pathological alteration of EGFRI-induced rash, we treated rat with vehicle or afatinib for 3 days. We then performed gene expression profiling analysis using data obtained from RNA-Seq of 3 different rat skins in each group为探究表皮生长因子受体抑制剂（Epidermal Growth Factor Receptor Inhibitor, EGFRI）诱导皮疹的早期病理改变，我们分别以赋形剂或阿法替尼处理大鼠，持续3天。随后，我们针对两组各3份独立大鼠皮肤样本的RNA测序（RNA Sequencing, RNA-Seq）数据开展基因表达谱分析。