Age-associated dysregulation of peroxisomal matrix protein importing impairs intestinal stem cell differentiation and gut functions

To determine the mechanism by which aspirin promotes ISC differentiation during senescence, RNA sequencing was performed on the dissected midguts of old Drosophila reared for 40 days at room temperature, with or without aspirin administration.

为探究阿司匹林在衰老进程中促进肠干细胞（Intestinal Stem Cell, ISC）分化的分子机制，本研究对室温条件下饲养40天的老龄果蝇解剖获取的中肠开展了RNA测序（RNA sequencing）实验，实验设置了阿司匹林给药组与未给药对照组。