Oligosymptomatic long-term carriers of SARS-CoV-2 display impaired innate resistance but increased high-affinity anti-Spike antibodies. Montes-Cobos et al.

Our aim was to compare the immune responses of mildly-symptomatic COVID-19 patients with regular course of infection to those of patients with persistent SARS-CoV-2 infection. These set of data was obtained from plasma and PBMCs purified from healthy human individuals (HC) and COVID-19 patients with either a short infection period (until 21 days after symptom onset, NP) or with long-term infection (detectable SARS-CoV-2 RNA by qRT-PCR in nasopharynx for longer than 21 days after symptoms onset, P). The data represent a set of plasma cytokines and flow cytometry imunophenotyping data obtained from frozen plasma and PBMCs from the refered study subjects. We observed significant diferents in several of the analyzed parameters between the study groups, indicating distinct immune responses defining the group of olygosymptomatic long-term infected patients.

本研究旨在对比感染进程为常规病程的轻症新型冠状病毒肺炎（COVID-19）患者，与持续性严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染患者的免疫应答特征。本数据集的样本来源于健康个体（Healthy Control，HC）以及两类新冠患者的血浆与纯化外周血单个核细胞（Peripheral Blood Mononuclear Cells，PBMCs）：一类为感染周期较短的患者（症状发作后21天内，记为NP组），另一类为长期感染患者（症状发作后21天以上仍可在鼻咽拭子中通过实时荧光定量逆转录聚合酶链反应（qRT-PCR）检测到SARS-CoV-2 RNA，记为P组）。本数据集包含来自上述研究对象的冻存血浆与PBMCs的血浆细胞因子及流式细胞术免疫表型分析数据。本研究在各组间的多项分析参数中观察到显著差异，提示少症状长期感染患者存在独特的免疫应答特征。