HSV-1 miRNAs are posttranscriptionaly edited in latently infected human ganglia

In this study, we comprehensively analyzed miRNAs in latently infected human tissues, mouse latency models, and productively infected cells in culture. The aim of this study was to investigate whether editing occurs in HSV-1 miRNAs, which can undergo various posttranscriptional modifications that may affect their biogenesis, stability, and targeting.

本研究对潜伏感染的人体组织、小鼠潜伏感染模型以及体外培养的产毒性感染细胞中的微小RNA（miRNAs）进行了全面分析。本研究旨在探究1型单纯疱疹病毒（HSV-1）的miRNAs是否存在编辑现象；此类RNA可经历多种转录后修饰，这些修饰或可影响其生物发生、稳定性及靶向功能。