Causal Links Between Gut Microbiota, Plasma Metabolites, and Insomnia: Insights from Mendelian Randomization

Table S1: Instrumental variables of gut microbiota after clumping and exclusion of week IVs; Table S2: Instrumental variables of plasma metabolites after clumping and exclusion of week IVs; Table S3: Causal effects of gut microbiota on insomnia (Forward MR analysis); Table S4: Causal effects of insomnia on identified gut microbiota (Reverse MR analysis); Table S5: Genetic correlation between identified gut microbiota and insomnia (LDSC analysis); Table S6: Causal associations between plasma metabolites and insomnia (Associations only with PIVW less than 0.05 and consistent with all sensitivity analysis were listed); Table S7: Causal associations between identified gut microbiota and 35 plasma metabolites; Table S8: Mediation analysis between gut microbiota, plasma metabolites, and insomnia.

补充表S1：经连锁不平衡聚类修剪并剔除第IV周工具变量后的肠道菌群工具变量（Instrumental Variables，IVs）；补充表S2：经连锁不平衡聚类修剪并剔除第IV周工具变量后的血浆代谢物工具变量；补充表S3：肠道菌群对失眠的因果效应（正向孟德尔随机化分析（Forward MR analysis））；补充表S4：失眠对已鉴定肠道菌群的因果效应（反向孟德尔随机化分析（Reverse MR analysis））；补充表S5：已鉴定肠道菌群与失眠之间的遗传相关性（连锁不平衡得分回归分析（LDSC analysis））；补充表S6：血浆代谢物与失眠的因果关联（仅列出逆方差加权法P值（PIVW）小于0.05且通过所有敏感性分析验证的关联结果）；补充表S7：已鉴定肠道菌群与35种血浆代谢物之间的因果关联；补充表S8：肠道菌群、血浆代谢物与失眠之间的中介分析