JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin

Here we identified JunB, a member of the AP-1 transcription factor family, regulated epidermal stem cells and sebaceous glands through balancing proliferation and differentiation of progenitors and by suppressing lineage infidelity. Transcriptome profiling of JunB deficient keratinocytes and post-wounded skin

本研究鉴定出AP-1转录因子家族（AP-1 transcription factor family）成员JunB，其可通过平衡祖细胞的增殖与分化、抑制细胞谱系偏离，调控表皮干细胞与皮脂腺的功能。本研究同时对JunB缺陷型角质形成细胞及创伤后皮肤开展了转录组分析。