Data for: FreeHi-C Spike-in Simulations for Benchmarking Differential Chromatin Interaction Detection

FreeHi-C Spike-in Simulations on GM12878 replicates 2, 3, 4, and 6 using different proportions of spike-ins which are simulated to different levels of sequencing depths. The spike-in set was determined by comparing four replicates of A549 with four replicates of GM12878 filtered by absolute log2 fold-changes 2.

针对GM12878细胞系的第2、3、4、6号生物学重复样本，开展FreeHi-C的spike-in模拟实验（Spike-in Simulations）；实验中采用不同比例的spike-in对照（Spike-in），并将其模拟至不同测序深度水平。该spike-in对照集通过对比A549细胞系的4个生物学重复样本与经以绝对log₂倍数变化值2为阈值筛选后的GM12878细胞系4个生物学重复样本确定。