Identification of Distinct Circulating miRNAs in Acute Ischemic Stroke Patients with Type 2 Diabetes Mellitus

We performed comprehensive miRNA profiling of ischemic stroke patients with or without type 2 diabetes mellitus (T2DM), an important risk factor associated with worse clinical outcomes in stroke. Serum samples were collected within 24 hrs of acute stroke diagnosis, and circulating miRNAs profiled using RNA-Seq were compared between stroke patients with T2DM (SWDM; n=92) and those without T2DM (SWoDM; n=98).

本研究针对伴或不伴2型糖尿病（T2DM）的缺血性脑卒中患者开展了全面的微小RNA（miRNA）表达谱分析——2型糖尿病是与脑卒中患者不良临床转归密切相关的重要危险因素。本研究于急性脑卒中确诊后24小时内采集血清样本，采用RNA测序（RNA-Seq）技术对循环微小RNA进行检测，并对比了伴2型糖尿病脑卒中患者（SWDM；n=92）与不伴2型糖尿病脑卒中患者（SWoDM；n=98）的检测结果。