dbCLINE Dataset

The dbCLINE dataset contains the results published in Hancock AM, Witonsky DB, Alkorta-Aranburu G, Beall CM, Gebremedhin A, Sukernik R, Utermann G, Pritchard JK, Coop G, Di Rienzo A. Adaptations to climate-mediated selective pressures in humans. PLoS Genet. 2011. Hancock AM, Witonsky DB, Ehler E, Alkorta-Aranburu G, Beall C, Gebremedhin A, Sukernik R, Utermann G, Pritchard J, Coop G, Di Rienzo A. Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency. Proc Natl Acad Sci U S A. 2010 Applying the method of Coop et al. (2010) , the Di Rienzo lab conducted a genome-wide study to identify regions associated with variation in 20 environmental variables across 61 worldwide populations (52 HGDP + 9 in house genotyped on the Illumina 650Y platform;. These results had been formerly found in the online dbCLINE database at http://genapps.uchicago.edu/dbcline. See README.txt for additional information. NOTE: The allele frequencies contained in these data for the Amhara population is for an increased sample size of 60 individuals, not the 22 specified in Hancock et al. 2011.dbCLINE数据集收录了以下已发表的研究成果： Hancock AM、Witonsky DB、Alkorta-Aranburu G、Beall CM、Gebremedhin A、Sukernik R、Utermann G、Pritchard JK、Coop G、Di Rienzo A. 人类对气候介导选择压力的适应性演化. 《公共科学图书馆·遗传学》（PLoS Genet）. 2011年. Hancock AM、Witonsky DB、Ehler E、Alkorta-Aranburu G、Beall C、Gebremedhin A、Sukernik R、Utermann G、Pritchard J、Coop G、Di Rienzo A. 专题论文：人类对饮食、生存方式与生态区的适应性演化源于等位基因频率的细微变化. 《美国国家科学院院刊》（Proc Natl Acad Sci U S A）. 2010年. 基于Coop等人（2010）的研究方法，Di Rienzo课题组开展了一项全基因组研究，旨在对全球61个人群（含52个人类基因组多样性计划（Human Genome Diversity Project, HGDP）人群与9个内部基因分型人群，后者采用Illumina 650Y基因分型平台）中与20种环境变量变异相关的基因组区域进行鉴定。上述研究结果此前已发布于在线dbCLINE数据库，网址为http://genapps.uchicago.edu/dbcline。 更多详细信息请参见README.txt文件。 注意：本数据集中阿姆哈拉（Amhara）人群的等位基因频率基于扩大后的60名样本量，而非Hancock等人2011年研究中提及的22名样本。