FAIRsharing record for: Bgee DataBase for Gene Expression Evolution

This FAIRsharing record describes: Bgee is a database for retrieval and comparison of gene expression patterns across multiple animal species. It provides an intuitive answer to the question "where is a gene expressed?" and supports research in cancer and agriculture as well as evolutionary biology.
Bgee data are produced from multiple data types (bulk and single-cell RNA-Seq, Affymetrix, in situ hybridization, EST data), and multiple data sets, that are all integrated consistently to provide a single answer to the question: "where is this gene expressed?"
Bgee is based exclusively on curated "normal", healthy wild-type expression data (e.g., no gene knock-out, no treatment, no disease), to provide a comparable reference of normal gene expression.
Bgee produces calls of presence/absence of expression, and of differential over-/under-expression, integrated along with information of gene orthology, and of homology between organs. This allows comparisons of expression patterns between species.

这个FAIRsharing记录描述了：Bgee是一个用于检索和比较多种动物物种间基因表达模式的数据库。它为“基因在何处表达？”这一问题提供直观答案，并支持癌症、农业及进化生物学领域的研究。
Bgee的数据来源于多种数据类型（批量和单细胞RNA测序（RNA-Seq）、Affymetrix芯片、原位杂交（in situ hybridization）、表达序列标签数据（EST data））以及多个数据集，所有数据均经过一致整合，以针对“该基因在何处表达？”这一问题提供统一答案。
Bgee完全基于经过人工整理的“正常”、健康野生型表达数据（例如无基因敲除、无处理、无疾病状态），旨在提供正常基因表达的可比参考。
Bgee生成基因表达存在/缺失的判断结果，以及差异过表达/低表达的分析结果，并整合了基因同源性（gene orthology）信息和器官间的同源关系信息。这使得跨物种的表达模式比较成为可能。