Polycyclic aromatic hydrocarbons induce endothelial injury through miR-155 to promote atherosclerosis

This study found that polycyclic aromatic hydrocarbons (PAHs) induced high expression of miR-155, which exaggerated atherosclerosis through directly targeted and down-regulated the expression of SERPIND1. Our study provides a fundamental insight into the miR-155 mechanism for PAHs enhancing atherosclerosis and miR-155 potentially serve as a novel drug target.

本研究发现，多环芳烃（polycyclic aromatic hydrocarbons，PAHs）可诱导miR-155高表达，后者通过直接靶向并下调丝氨酸蛋白酶抑制剂家族D成员1（SERPIND1）的表达，加剧动脉粥样硬化进程。本研究为阐明多环芳烃促进动脉粥样硬化的miR-155作用机制提供了基础性理论见解，且miR-155有望成为新型药物靶点。