ATN 071 Brief Visuospatial Memory Test Revised (BVMT-R): Primary Scores Dataset in Neurocognitive Assessment in Youth Initiating HAART

Data from Brief Visuospatial Memory Test Revised (BVMT-R): Primary Scores [CRF f5bvpr]
Study Description
A prospective cohort study comparing neurocognitive functioning in four groups of youth, ages 18-24 years, with behaviorally acquired HIV infection: two groups with CD4+ T-cells greater than 350 cells/mm3 and HIV RNA equal to or greater than 1,000 copies/ml - one initiating early highly active antiretroviral therapy (HAART) (Group 1), the other not initiating treatment (Group 2); and two groups with CD4+ T-cells less than 350 cells/mm3 - one initiating HAART according to then current DHHS guidelines (Group 3), the other not initiating treatment (Group 4). Groups 2 and 3 represented standard of care. The study provided preliminary data to test the hypothesis that initiating HAART earlier than DHHS guidelines suggested at that time resulted in better neurocognitive function in comparison with no treatment or treatment initiated according to DHHS recommendations. Youth ages 18-24 years with behaviorally acquired HIV infection

简短视觉空间记忆测验修订版(Brief Visuospatial Memory Test Revised, BVMT-R)原始得分数据集[CRF f5bvpr]
研究概况
本研究为一项前瞻性队列研究，旨在比较4组18~24岁经性行为感染人类免疫缺陷病毒（Human Immunodeficiency Virus, HIV）青年的神经认知功能：两组CD4+T淋巴细胞计数＞350 cells/mm³且HIV RNA≥1000 copies/ml的亚组，其中一组早期启动高效抗反转录病毒治疗（highly active antiretroviral therapy, HAART）（第1组），另一组未启动治疗（第2组）；另外两组CD4+T淋巴细胞计数＜350 cells/mm³的亚组，其中一组按照当时美国卫生与人类服务部（Department of Health and Human Services, DHHS）指南启动HAART治疗（第3组），另一组未启动治疗（第4组）。第2组与第3组代表当时的标准治疗方案。本研究提供了初步数据，用于验证下述假说：相较于未接受治疗或按照DHHS指南推荐启动治疗者，提前启动HAART（早于当时DHHS指南建议的时机）可获得更优的神经认知功能。本研究纳入人群为18~24岁经性行为感染HIV的青年。