National Child Development Study: Proteomics: Special Licence, 2002-2004

Name: National Child Development Study: Proteomics: Special Licence, 2002-2004
Creator: UK Data Service
Published: 2024-11-29 07:26:00
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Abstract copyright UK Data Service and data collection copyright owner.The National Child Development Study (NCDS) is a continuing longitudinal study that seeks to follow the lives of all those living in Great Britain who were born in one particular week in 1958. The aim of the study is to improve understanding of the factors affecting human development over the whole lifespan.  The NCDS has its origins in the Perinatal Mortality Survey (PMS) (the original PMS study is held at the UK Data Archive under SN 2137). This study was sponsored by the National Birthday Trust Fund and designed to examine the social and obstetric factors associated with stillbirth and death in early infancy among the 17,000 children born in England, Scotland and Wales in that one week. Selected data from the PMS form NCDS sweep 0, held alongside NCDS sweeps 1-3, under SN 5565.  Survey and Biomeasures Data (GN 33004): To date there have been nine attempts to trace all members of the birth cohort in order to monitor their physical, educational and social development. The first three sweeps were carried out by the National Children's Bureau, in 1965, when respondents were aged 7, in 1969, aged 11, and in 1974, aged 16 (these sweeps form NCDS1-3, held together with NCDS0 under SN 5565). The fourth sweep, also carried out by the National Children's Bureau, was conducted in 1981, when respondents were aged 23 (held under SN 5566). In 1985 the NCDS moved to the Social Statistics Research Unit (SSRU) - now known as the Centre for Longitudinal Studies (CLS). The fifth sweep was carried out in 1991, when respondents were aged 33 (held under SN 5567). For the sixth sweep, conducted in 1999-2000, when respondents were aged 42 (NCDS6, held under SN 5578), fieldwork was combined with the 1999-2000 wave of the 1970 Birth Cohort Study (BCS70), which was also conducted by CLS (and held under GN 33229). The seventh sweep was conducted in 2004-2005 when the respondents were aged 46 (held under SN 5579), the eighth sweep was conducted in 2008-2009 when respondents were aged 50 (held under SN 6137) and the ninth sweep was conducted in 2013 when respondents were aged 55 (held under SN 7669).  Four separate datasets covering responses to NCDS over all sweeps are available. National Child Development Deaths Dataset: Special Licence Access (SN 7717) covers deaths; National Child Development Study Response and Outcomes Dataset (SN 5560) covers all other responses and outcomes; National Child Development Study: Partnership Histories (SN 6940) includes data on live-in relationships; and National Child Development Study: Activity Histories (SN 6942) covers work and non-work activities. Users are advised to order these studies alongside the other waves of NCDS. From 2002-2004, a Biomedical Survey was completed and is available under End User Licence (EUL) (SN 8731) and Special Licence (SL) (SN 5594). Proteomics analyses of blood samples are available under SL SN 9254. Linked Geographical Data (GN 33497):  A number of geographical variables are available, under more restrictive access conditions, which can be linked to the NCDS EUL and SL access studies.  Linked Administrative Data (GN 33396): A number of linked administrative datasets are available, under more restrictive access conditions, which can be linked to the NCDS EUL and SL access studies. These include a Deaths dataset (SN 7717) available under SL and the Linked Health Administrative Datasets (SN 8697) available under Secure Access. Additional Sub-Studies (GN 33562): In addition to the main NCDS sweeps, further studies have also been conducted on a range of subjects such as parent migration, unemployment, behavioural studies and respondent essays. The full list of NCDS studies available from the UK Data Service can be found on the <a href="https://beta.ukdataservice.ac.uk/datacatalogue/series/series?id=2000032#!/access-data" target="_blank" style="background-color: rgb(255, 255, 255);">NCDS</a> series access data webpage.   How to access genetic and/or bio-medical sample data from a range of longitudinal surveys: For information on how to access biomedical data from NCDS that are not held at the UKDS, see the <a href="https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples/" target="_blank" style="background-color: rgb(255, 255, 255);">CLS Genetic data and biological samples</a> webpage. Further information about the full NCDS series can be found on the <a href="https://cls.ucl.ac.uk/cls-studies/1958-national-child-development-study/" target="_blank" style="background-color: rgb(255, 255, 255);">Centre for Longitudinal Studies</a> website.  National Child Development Study: Proteomics: Special Licence, 2002-2004 Proteomics analyses were run on the blood samples collected from NCDS participants in 2002-2004. This will substantially enhance NCDS and catalyse a step change in our understanding of the relationship between exposures from birth to midlife and their consequences for multiple physical and mental health disorders. It will provide high-dimensional biological information on these individuals during early midlife (aged 42 to 44), prior to the onset of most chronic disease, and at an age that is underrepresented in most cohorts, including UK Biobank (UKB). Embedding this technology within NCDS with linkage to existing genetics and biomarker data, repeat measures of social and biomedical exposures, and pre-clinical and clinical disease outcomes will drive a major uptake in NCDS data use, including by large-scale international academic consortia aiming to understand the determinants of healthy ageing.<div> </div> Main Topics: Proteomics analysis on blood samples collected at age 42.

摘要版权归英国数据服务（UK Data Service）及数据收集版权所有者所有。《全国儿童发展研究》（National Child Development Study，简称NCDS）是一项持续的纵向研究，旨在追踪1958年某一周内出生于大不列颠的所有个体的生命历程。该研究的目标是增进对影响人类整个生命周期发展的因素的理解。 NCDS起源于围产期死亡率调查（Perinatal Mortality Survey，简称PMS）（原始PMS研究由英国数据档案库以SN 2137编号保存）。这项研究由全国生日信托基金（National Birthday Trust Fund）赞助，旨在考察17000名于该周出生在英格兰、苏格兰和威尔士的儿童中，与死胎及婴儿早期死亡相关的社会和产科因素。选自PMS的数据构成了NCDS第0次调查（sweep 0），与NCDS第1至3次调查一同以SN 5565编号保存。 调查与生物测量数据（GN 33004）： 截至目前，已进行九次尝试以追踪该出生队列的所有成员，监测其身体、教育及社会发展情况。前三次调查由全国儿童局于1965年（受访者年龄7岁）、1969年（11岁）及1974年（16岁）开展（这些调查构成NCDS1-3，与NCDS0一同以SN 5565编号保存）。第四次调查同样由全国儿童局于1981年开展（受访者年龄23岁，以SN 5566编号保存）。1985年，NCDS转至社会统计研究单位（Social Statistics Research Unit，简称SSRU）——现更名为纵向研究中心（Centre for Longitudinal Studies，简称CLS）。第五次调查于1991年开展（受访者年龄33岁，以SN 5567编号保存）。第六次调查于1999-2000年进行（受访者年龄42岁，即NCDS6，以SN 5578编号保存），其田野工作与CLS同期开展的《1970年出生队列研究》（1970 Birth Cohort Study，简称BCS70）1999-2000年波次相结合（BCS70以GN 33229编号保存）。第七次调查于2004-2005年开展（受访者年龄46岁，以SN 5579编号保存），第八次于2008-2009年开展（50岁，SN 6137），第九次于2013年开展（55岁，SN 7669）。 现有四个独立数据集涵盖所有调查的响应结果：《全国儿童发展研究死亡数据集：特殊许可访问》（SN 7717）覆盖死亡数据；《全国儿童发展研究响应与结果数据集》（SN 5560）覆盖其他所有响应及结果；《全国儿童发展研究：伴侣关系史》（SN 6940）包含同居关系数据；《全国儿童发展研究：活动史》（SN 6942）覆盖工作及非工作活动。建议用户在获取NCDS其他波次数据时一并订购这些研究数据集。 2002-2004年完成的生物医学调查数据可通过终端用户许可（End User Licence，简称EUL，SN 8731）及特殊许可（Special Licence，简称SL，SN 5594）获取。血液样本的蛋白质组学分析（Proteomics analysis）数据可通过特殊许可SN 9254获取。 关联地理数据（GN 33497）： 现有若干地理变量数据，可关联至NCDS的EUL及SL访问研究数据集，但访问条件更为严格。 关联行政数据（GN 33396）： 现有若干关联行政数据集，可关联至NCDS的EUL及SL访问研究数据集，访问条件更为严格。这些数据集包括特殊许可下的《死亡数据集》（SN 7717）及安全访问下的《关联健康行政数据集》（SN 8697）。 附加子研究（GN 33562）： 除NCDS主调查外，还开展了一系列主题的进一步研究，如父母迁移、失业、行为研究及受访者随笔等。英国数据服务提供的所有NCDS研究数据集完整列表可在<a href="https://beta.ukdataservice.ac.uk/datacatalogue/series/series?id=2000032#!/access-data" target="_blank" style="background-color: rgb(255, 255, 255);">NCDS</a>系列数据访问网页查询。 如何从各类纵向调查中获取遗传和/或生物医学样本数据： 如需了解如何获取未存于英国数据服务（UKDS）的NCDS生物医学数据，请参阅<a href="https://cls.ucl.ac.uk/data-access-training/genetic-data-and-biological-samples/" target="_blank" style="background-color: rgb(255, 255, 255);">CLS遗传数据与生物样本</a>网页。 关于完整NCDS系列的更多信息可在<a href="https://cls.ucl.ac.uk/cls-studies/1958-national-child-development-study/" target="_blank" style="background-color: rgb(255, 255, 255);">纵向研究中心</a>网站查询。 全国儿童发展研究：蛋白质组学分析：特殊许可，2002-2004 对2002-2004年采集的NCDS参与者血液样本进行了蛋白质组学分析。这将显著增强NCDS的价值，并推动我们对从出生到中年的暴露因素与其对多种身心疾病后果之间关系的理解发生质的飞跃。该分析将提供这些个体在中年早期（42至44岁）的高维度生物学信息——此时多数慢性疾病尚未发作，且该年龄段在包括英国生物样本库（UK Biobank，简称UKB）在内的多数队列研究中代表性不足。 将这项技术嵌入NCDS，并关联现有遗传和生物标志物数据、社会与生物医学暴露的重复测量数据及临床前和临床疾病结果，将大幅提升NCDS数据的使用率，包括吸引旨在理解健康老龄化决定因素的大型国际学术联盟使用。<div> </div> 主要主题: 对42岁时采集的血液样本进行蛋白质组学分析。

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UK Data Service

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2024-04-23

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