Opportunistic pathogen that causes important food-borne disease

Diarrhoea is a condition with severe public health concerns due to its high morbidity and mortality on infected individuals. Despite the variation in the etiology of diarrhoea, diarrhoeagenic bacteria (DGB) are of significant importance due to their potential to cause life-threatening complications in humans. These pathogens are transmitted via the faecal-oral route and the consumption of contaminated food is considered a principal route for their transmission. Cattle have been identified as main reservoir of diarrhoeal pathogens with frequent surveillance studies serving as a crucial strategy to safe-guard public health and also generate epidemiological data. Surveillance studies also provide an opportunity to understand current trends in the development and dissemination of antimicrobial resistance (AMR) in both the human population as well as environmental sources. Data on AMR patterns may guide treatment options but also enhance efforts in the search for alternative non-antibiotic agents.

腹泻是一类备受公共卫生高度关注的疾病，因其会对感染者造成极高的发病率与死亡率。尽管腹泻的病因存在多样性，但致泻性细菌（diarrhoeagenic bacteria, DGB）因其可引发人类致死性并发症的潜能，具有极为重要的公共卫生意义。此类病原体通过粪-口途径传播，食用受污染食物被认为是其主要传播方式。牛已被确定为腹泻病原体的主要储存宿主，而常态化监测研究既是保障公共卫生的关键策略，也是获取流行病学数据的重要途径。监测研究还有助于了解人类群体与环境来源中抗菌素耐药性（antimicrobial resistance, AMR）的发展与传播现状。抗菌素耐药性模式相关数据既能为临床治疗方案提供指导，也能助力非抗生素替代疗法的研发工作。