Dataset from Women's Health Initiative (WHI)

To address cardiovascular disease, cancer, and osteoporosis, the most common causes of death, disability, and impaired quality of life in postmenopausal women. The three major components of the WHI are: a randomized controlled clinical trial of hormone replacement therapy (HRT), dietary modification (DM), and calcium/vitamin D supplementation (CaD); an observational study (OS); and a community prevention study (CPS). On October 1, 1997, administration of the WHI was transferred to the NHLBI where it is conducted as a consortium effort led by the NHLBI in cooperation with the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Cancer Institute (NCI), and the National Institute on Aging (NIA).

心血管疾病、癌症及骨质疏松症是导致绝经后女性死亡、残疾与生活质量受损的三大最常见病因。为应对此类健康问题，妇女健康倡议（Women's Health Initiative, WHI）包含三大核心组成部分：其一为针对激素替代疗法（Hormone Replacement Therapy, HRT）、饮食干预（Dietary Modification, DM）以及钙/维生素D补充剂（Calcium/Vitamin D Supplementation, CaD）的随机对照临床试验；其二为观察性研究（Observational Study, OS）；其三为社区预防研究（Community Prevention Study, CPS）。1997年10月1日，WHI的项目管理工作移交至美国国家心肺血液研究所（National Heart, Lung, and Blood Institute, NHLBI），该研究由NHLBI牵头，与美国国家关节炎、肌肉骨骼与皮肤疾病研究所（National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIAMS）、美国国家癌症研究所（National Cancer Institute, NCI）以及美国国家衰老研究所（National Institute on Aging, NIA）合作，以联盟协作模式开展实施。