Nuclear Genome Organization in Fungi: From Gene folding to Rabl Chromosomes

We discuss the current knowledge on the fungal genome organization, from the association of chromosomes within the nucleus to topological structures at individual genes and the genetic factors required for the hierarchical organization. Chromosome conformation capture followed by high-throughput sequencing (Hi-C) has elucidated how fungal genomes are globally organized in Rabl configuration where centromere or telomere bundles are associated with opposite faces of the nuclear envelope. Here, we explore the presence, in fungal taxa, of the typical proteins associated with genome organization in eukaryotes.本研究梳理当前学界关于真菌基因组组织结构的既有认知，涵盖从细胞核内染色体的关联模式，到单个基因的拓扑结构，以及层级化基因组组织所需的遗传因素。通过染色体构象捕获结合高通量测序（Hi-C）技术，学界已阐明真菌基因组在全局层面以拉布尔（Rabl）构型排布：着丝粒束或端粒束与核被膜的相对两侧相结合。本研究旨在探究真菌类群中是否存在与真核生物基因组组织结构相关的典型蛋白。