Additional file 1 of Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer’s disease pathology: a clinicopathological study

Additional file 1: Supplemental Figure 1. Example of PET ROI hand drawn to match pathology sample block, in this case right amygdala. Note the PET image is in radiologic orientation so the relevant ROI for this example is on the left of the image (blue). Supplemental Figure 2. Correlation between regional flortaucipir SUVr and Histelide estimate of regional Ptau in individual subjects. Blue symbols, regression line and Pearson’s r are for cortical regions. Green symbols reflect limbic regions: hippocampus/entorhinal cortex and amygdala. Red symbols represent subcortical regions: caudate/putamen, basal ganglia/nucleus basalis, thalamus. Supplementary Table.

附加文件1：补充图1。本示例展示了为匹配病理样本块而手绘的PET感兴趣区（Region of Interest, ROI），本例的目标区域为右侧杏仁核。请注意，本PET图像采用放射学定位视角，因此本例的目标感兴趣区位于图像左侧（以蓝色标记）。补充图2：单受试者区域氟托他匹（flortaucipir）标准化摄取值比（SUVr）与Histelide检测的区域磷酸化tau蛋白（Ptau）估计值之间的相关性。其中，蓝色符号、回归直线与皮尔逊相关系数（Pearson’s r）均对应大脑皮层区域；绿色符号代表边缘系统区域，包括海马体/内嗅皮层与杏仁核；红色符号代表皮层下区域，涵盖尾状核/壳核、基底神经节/基底核以及丘脑。补充表格。