Metformin Data set

Insulin resistance is being increasingly reported in type-1 Diabetes (T1D) and is known to accelerate microvascular complications. The Asian Indian population has a higher risk of double diabetes development compared to Caucasians. Hence, we studied the effect of adding Metformin to standard insulin therapy in Indian adolescents with T1D on glycemic control, insulin sensitivity (IS), cardiometabolic parameters and body composition.

胰岛素抵抗在1型糖尿病（type-1 Diabetes, T1D）中的报道日益增多，且已知其会加速微血管并发症的发生发展。相较于白种人群，亚洲印度裔群体罹患双重糖尿病的风险更高。因此，本研究针对印度裔1型糖尿病青少年群体，探讨了在标准胰岛素治疗方案基础上加用二甲双胍（Metformin）对血糖控制、胰岛素敏感性（insulin sensitivity, IS）、心脏代谢参数以及身体成分的影响。