Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma

Currently, no articles have explored the roles of RRAGB gene in the occurrence and development of cancer. By means of The Cancer Genome Atlas (TCGA) data mining, we found that this gene might be a novel prognostic predictor for colon adenocarcinoma (COAD). Hence, this article was carried out to explore its roles in COAD and associations with immunity. RRAGB single-gene expression matrix and corresponding clinical information were extracted from TCGA database. Univariate/multivariate cox regression analyses and gene set enrichment analysis (GSEA) were utilized to identify independent prognostic factors and RRAGB related pathways, respectively. Relationships between RRAGB and immunity were also analyzed. Boxplot and K-M survival analysis indicated that RRAGB was not only differently expressed in COAD (P P P

目前尚无相关研究探讨RRAGB基因在癌症发生与发展过程中的作用。本研究通过癌症基因组图谱（The Cancer Genome Atlas, TCGA）数据库开展数据挖掘，发现该基因或可成为结肠腺癌（colon adenocarcinoma, COAD）的新型预后预测标志物。为此，本文旨在探究RRAGB基因在结肠腺癌中的作用及其与免疫的关联。我们从TCGA数据库中提取了RRAGB单基因表达矩阵及其对应的临床信息。分别运用单变量/多变量Cox回归分析（univariate/multivariate cox regression analyses）与基因集富集分析（gene set enrichment analysis, GSEA），以明确独立预后因子及RRAGB相关信号通路。同时对RRAGB与免疫的相关性进行了分析。箱线图（Boxplot）与Kaplan-Meier生存分析（K-M survival analysis）结果表明，RRAGB在结肠腺癌组织中存在差异表达（P P P