Total RNA Sequencing in Eyeballs isolated from Tetraselmis chuii treated Dry Eye Sydrome Mice. Total RNA Sequencing in Eyeballs isolated from Tetraselmis chuii treated Dry Eye Sydrome Mice

The purpose of this study was to compare changes in gene expression in the eyeballs following ingestion of Tetraselmis chuii (T. chuii) in a BALB/C mouse model of dry eye syndrome (DES). The changes in gene expression before and after DES induction were compared preferentially, as were the changes in gene expression caused by T. chuii ingestion following DES induction Overall design: We analyzed the gene expression patterns of eyeballs derived from WT, dry eye syndrome by inducing scoplamine, and T. chuii treated dry eye syndrome mice using RNAseq

本研究旨在对比干眼综合征（dry eye syndrome, DES）BALB/C小鼠模型中，摄入四列藻（Tetraselmis chuii, T. chuii）后眼球的基因表达变化。研究优先对比了干眼诱导前后的基因表达变化，同时也对比了干眼诱导后摄入四列藻所引发的基因表达变化。整体实验设计：我们采用RNA测序（RNAseq）技术，分析了野生型（WT）、东莨菪碱诱导干眼综合征小鼠，以及经四列藻干预的干眼综合征小鼠的眼球基因表达模式。