Effect of the chromosome 1 locus on white blood cell counts.

*European ancestry at the locus has an essentially dominant effect on white blood cell counts. None of the differential counts phenotypes shows a significant difference between the 1,647 FY−/FY+ heterozygotes and 247 FY+/FY+ homozygotes after correcting for 7 hypotheses tested (Bonferroni corrected P = 0.48). However, all white blood cell counts except bands show significant associations comparing the 4,111 FY−/FY− homozygotes to the 1,894 carriers of the FY+ allele (Z-scores between 4.2 and 49.7 standard deviations).
†After controlling for neutrophil level, there is weak additional evidence for association to the chromosome 1 locus only for monocytes and basophils. For subsequent mapping analyses we only focused on neutrophil levels, as adding these other residuals did not substantially increase the strength of the association. We do not estimate correlation coefficients of the associations that are not significant.

该基因座（locus）的欧洲血统对白细胞计数具有本质上的显性效应。在对7项检验假设进行邦费罗尼（Bonferroni）校正后，1647例FY−/FY+杂合子与247例FY+/FY+纯合子之间的所有白细胞分类计数表型均未呈现显著差异（邦费罗尼校正后P=0.48）。然而，将4111例FY−/FY−纯合子与1894例FY+等位基因（allele）携带者进行对照分析时，除杆状核粒细胞外，所有白细胞计数均显示出显著关联（Z值介于4.2至49.7个标准差之间）。
†在控制中性粒细胞水平这一协变量后，仅单核细胞和嗜碱性粒细胞存在与1号染色体基因座相关的微弱额外关联证据。在后续的基因定位分析中，我们仅聚焦于中性粒细胞水平，因为纳入其余残差并未显著增强关联强度。本研究未对无统计学显著性的关联估算相关系数。