Lipinski rule of five criteria for compound series.

NIAID Data Ecosystem2026-05-02 收录

药物化学筛选

成药性预测

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Lipinski rule of five criteria for compound series.

化合物系列的类药五规则（Lipinski Rule of Five）判定标准

创建时间：

2025-02-03

Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds

药物化学筛选

结构-活性关系

Target- and phenotype-agnostic assessments of biological activity have emerged as viable strategies for prioritizing scaffolds, structural features, and synthetic pathways in screening sets, with the

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Data for: Optimization of Novel Reversible Bruton's Tyrosine Kinase Inhibitors Identified using Tethering-Fragment-Based Screens

抑制剂优化

药物化学筛选

Kinases selectivity data for compounds 43 and 50. Analytical data for the synthesis of compound 50. Cellular IC50 graphs.

Mendeley Data2019-05-25 更新20

Effects of 1,3,4-thiadiazolium derivatives on MDR cell parameters.

多药耐药性

药物化学筛选

The experimental conditions are described in the Materials and Methods, sections 2.5.1 and 2.9. The efficiency of each mesoionic derivative to inhibit the efflux of fluorescent substrates was determin

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Prediction of antibacterial compounds as drugs (http://www.organic-chemistry.org).

成药性预测

毒性评估

acompounds to have a reasonable propability of being well absorbt their logP value must not be greater than 5.0. bmore than 80% of the drugs on the market have a (estimated) logS value greater than −4

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Supplementary data for "Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core"

整合素抑制剂发现

药物化学筛选

Supplementary dataset related to the paper: "Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core Integrins αvβ5 and αvβ3 are closely related, proangio

DataCite Commons2021-02-18 更新20

Lipinski rule of five criteria for compound series.

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