Data Sheet 1_Metabolic response to burn injury: a comprehensive bibliometric study.zip

ObjectiveBurns lead to systemic changes manifested by systemic disturbances in water-electrolyte balance and systemic metabolic and inflammatory responses. The hypermetabolic response after a burn injury relies on metabolic, hormonal, and inflammatory dysregulation mechanisms. This study aimed to provide a comprehensive bibliometric analysis of the burn metabolism research field, identifying key trends, influential contributors, and emerging research hotspots to inform future investigative efforts. Ultimately, we conducted an extensive review of the literature, synthesizing the findings to clarify the present understanding within our field of study.
MethodsWe obtained 8,823 scientific publications on burn injury and metabolism from the core Web of Science (WOS) database collection. In this work, biblioshiny was used to visualize and analyze the data, and VOSviewer was used to verify the results.
ResultsFrom a total of 8,823 publications, we found a general upward trend in annual publications and citation frequency. According to Bradford’s Law, 21 high-production journals were classified as core sources based on the number of publications, and the most productive journal was Burns. The most published countries and authors in this field were the United States and Herndon DN. The most local cited document in this field was the article titled “Catecholamines: Mediator of the Hypermetabolic Response to Thermal Injury” authored by Wilmore DW. The thematic map showed that studies on injury, thermal injury, and sepsis were relatively mature. In contrast, research on metabolism, stress, and responses, and research on mortality, resistance, and management were less well-developed but were essential for the field.
ConclusionResearch on burns and metabolism is increasing. Based on the bibliometric analysis, our study summarized the complex interplay between burn-induced systemic metabolic alterations and inflammatory responses, emphasizing the significance of hypermetabolism and its management. The role of propranolol, insulin, oxandrolone, and nutritional interventions in modulating the hypermetabolic state was discussed. Additionally, our study underscored the challenges of managing sepsis and drug-resistant infections in burn patients as an important future area of research.

烧伤可引发全身系统性改变，表现为水电解质平衡紊乱以及全身代谢与炎症反应异常。烧伤后高代谢反应的发生依赖于代谢、内分泌及炎症失调机制。本研究旨在对烧伤代谢研究领域开展全面的文献计量分析，明确该领域的关键研究趋势、高影响力贡献者与新兴研究热点，为后续研究工作提供参考。最终，我们对相关文献进行了系统性梳理，并整合分析现有研究成果，以阐明当前该领域的研究认知现状。
方法 我们从Web of Science (WOS)核心合集数据库中获取了8823篇关于烧伤与代谢的学术文献。本研究采用biblioshiny对数据进行可视化与分析，并使用VOSviewer对分析结果进行验证。
结果 在总计8823篇文献中，我们发现年度发文量与总引用频次均呈现整体上升趋势。根据布拉德福定律（Bradford’s Law），按发文量筛选出21种核心来源期刊，其中发文量最高的期刊为《Burns》。该领域发文量最多的国家为美国，最高产作者为Herndon DN。该领域内被引频次最高的文献为Wilmore DW撰写的题为《Catecholamines: Mediator of the Hypermetabolic Response to Thermal Injury》的论文。主题图谱显示，关于损伤、热损伤与脓毒症的研究相对成熟；而关于代谢、应激及应答，以及关于死亡率、耐药性与临床管理的研究虽发展相对不足，但却是该领域的核心研究方向。
结论 烧伤与代谢相关研究的数量正逐年增长。基于本次文献计量分析，本研究总结了烧伤诱导的全身代谢改变与炎症反应之间的复杂相互作用，强调了高代谢状态及其临床管理的重要性。本文还讨论了普萘洛尔、胰岛素、氧雄龙以及营养干预手段在调节高代谢状态中的作用。此外，本研究指出，烧伤患者脓毒症与耐药感染的管理挑战是未来重要的研究方向。