We found Nlrp12–/– mice harbors a dysbiotic microbiome during the 20-weeks of high fat diet compared to the WT mice.

Unhealthy diet changes host's commensal microbiota (dysbiosis). We found loss of NLRP12 exacerbate this diet-induced dysbiosis. During the period of 20 weeks HFD, Nlrp12–/– mice developed a dysbiotic microbiome featured a decreased of beneficial commensal bacterial groups (Clostridiales and Lachnospiraceae) but increased immunogenic bacterial groups (Erysipelotrichaceae). We collected the fecal samples at 1, 5 and 15 weeks of HFD, and found these changes processed correlated with the obesity progression.

不良饮食可改变宿主共生微生物群，引发菌群失调（dysbiosis）。本研究发现，NLRP12基因缺失会加剧此类饮食诱导的菌群失调。在为期20周的高脂饮食（HFD）干预期间，Nlrp12基因敲除（Nlrp12–/–）小鼠的微生物组呈现菌群失调特征：有益共生细菌类群（梭菌目Clostridiales与毛螺菌科Lachnospiraceae）丰度下降，而免疫原性细菌类群（丹毒丝菌科Erysipelotrichaceae）丰度升高。我们于高脂饮食干预的第1、5和15周采集粪便样本，发现上述菌群变化与肥胖进展密切相关。