Epidemiological Trends of Dengue Disease in Mexico (2000–2011): A Systematic Literature Search and Analysis

This systematic literature review describes the epidemiology of dengue disease in Mexico (2000–2011). The annual number of uncomplicated dengue cases reported increased from 1,714 in 2000 to 15,424 in 2011 (incidence rates of 1.72 and 14.12 per 100,000 population, respectively). Peaks were observed in 2002, 2007, and 2009. Coastal states were most affected by dengue disease. The age distribution pattern showed an increasing number of cases during childhood, a peak at 10–20 years, and a gradual decline during adulthood. All four dengue virus serotypes were detected. Although national surveillance is in place, there are knowledge gaps relating to asymptomatic cases, primary/secondary infections, and seroprevalence rates of infection in all age strata. Under-reporting of the clinical spectrum of the disease is also problematic. Dengue disease remains a serious public health problem in Mexico.

本系统综述阐述了2000年至2011年墨西哥登革热的流行病学特征。报告的非复杂性登革热年病例数从2000年的1714例增长至2011年的15424例，对应发病率分别为每10万人1.72例和14.12例。疫情分别在2002年、2007年及2009年出现峰值。沿海各州受登革热影响最为严重。年龄分布模式显示，儿童期病例数随年龄增长逐步上升，于10-20岁年龄段达到峰值，成年后则逐渐下降。本次研究共检出全部4种登革病毒血清型。尽管墨西哥已建立国家级疾病监测体系，但仍存在多项认知空白：涵盖无症状病例、原发/继发感染以及各年龄层人群的感染血清阳性率相关研究匮乏。登革热临床谱的漏报问题同样严峻。登革热仍是墨西哥面临的重大公共卫生挑战。