190806_JH_HK0200_PlexinD1LSLflp_SSp_S1hindlimb_female

An essential step toward a comprehensive understanding of brain function is to establish a cellular-resolution structural framework upon which multiscale and multi-modal information spanning molecules, cells, circuits, systems and behavior can be registered, integrated, interpreted and mined. Dr. Huang and Arlotta will lead the Center to produce two complementary cell atlases integrated within a digital Common Coordinate Framework of the mouse brain: 1) a Brainwide Cell Transcriptome Atlas of unprecedented scale and resolution, integrated with 2) an in-depth Forebrain Projection Neuron Atlas that combines comprehensive anatomic and molecular information.

全面理解脑功能的关键一步，是建立一个细胞分辨率的结构框架，在此框架下可对跨越分子、细胞、回路、系统及行为层面的多尺度、多模态信息进行配准、整合、解读与挖掘。Huang博士与Arlotta将领导该中心，在小鼠脑的数字化通用坐标框架（Common Coordinate Framework）内生成两个互补的细胞图谱并实现整合：1）规模与分辨率均前所未有的全脑细胞转录组图谱（Brainwide Cell Transcriptome Atlas）；2）结合全面解剖与分子信息的深度前脑投射神经元图谱（Forebrain Projection Neuron Atlas）。