Investigating Gut Microbiota-Blood and Urine Metabolite Correlations in Early Sepsis-Induced Acute Kidney Injury: Insights from Targeted KEGG Analyses

Sepsis-associated acute kidney injury (SA-AKI) is a life-threatening condition. This study employed metagenomics and metabolomics to analyze the gut microbiota and metabolites changes in nine patients, including four with SA-AKI and five without. We observed significant differences in gut microbiota composition and metabolic profiles between the groups, highlighting the crucial role of the gut-kidney axis in the early stages of sepsis. This connection could offer insights and potential targets for managing SA-AKI.

脓毒症相关性急性肾损伤（Sepsis-associated acute kidney injury，SA-AKI）是一种危及生命的临床病症。本研究采用宏基因组学与代谢组学技术，对9名受试者的肠道菌群及代谢物变化进行分析，其中4名患有脓毒症相关性急性肾损伤，剩余5名未患该病症。研究结果显示，两组患者的肠道菌群组成与代谢谱均存在显著差异，凸显了肠-肾轴在脓毒症早期阶段的关键作用。这一关联可为脓毒症相关性急性肾损伤的临床管理提供新思路与潜在干预靶点。