Catabolite Repression of Escherichia coli Biofilm Formation

Biofilm formation was repressed by glucose in several species of Enterobacteriaceae. In Escherichia coli, this effect was mediated at least in part by cyclic AMP (cAMP)-cAMP receptor protein. A temporal role for cAMP in biofilm development was indicated by the finding that glucose addition after ∼24 h failed to repress and generally activated biofilm formation.

肠杆菌科（Enterobacteriaceae）多个菌种的生物被膜（biofilm）形成可被葡萄糖抑制。在大肠杆菌（Escherichia coli）中，这一抑制效应至少部分由环腺苷酸（cyclic AMP，cAMP）-cAMP受体蛋白介导。研究发现，在约24小时后添加葡萄糖则无法再抑制生物被膜形成，反而通常会促进其生成，这表明cAMP在生物被膜发育过程中具有时间依赖性的调控作用。