Supporting data for "STUDIES ON TRANSITION METAL-CATALYZED ASYMMETRIC REDUCTIONS AND REDUCTIVE AMINATIONS"

The dataset includes the general information and experimental details of the PhD thesis "STUDIES ON TRANSITION METAL-CATALYZED ASYMMETRIC REDUCTIONS AND REDUCTIVE AMINATIONS". The development of efficient methods to construct diverse chiral molecules is important to organic synthesis and medicinal chemistry. The related works the synthesis of chiral alcohols and amines are in this dataset. We established a broadly applicable synthesis of enantioenriched NH lactams through a one-pot asymmetric reductive amination/cyclization sequence of easily available keto acids/esters. Furthermore, an efficient and straightforward strategy to synthesize enantio-enriched N-unprotected α-amino acetals via ruthenium-catalyzed direct asymmetric reductive amination was then achieved. In addition, we also developed an asymmetric 1,2-reduction of cyclic α, β-unsaturated ketones to access various enantiomerically enriched cyclic allylic alcohols under mild conditions, catalyzed by in situ generated copper hydride ligated with (R)-DTBM-C3*-TunePhos.

本数据集包含博士论文《过渡金属催化的不对称还原及还原胺化研究》（STUDIES ON TRANSITION METAL-CATALYZED ASYMMETRIC REDUCTIONS AND REDUCTIVE AMINATIONS）的基本信息与实验细节。开发高效构建多样手性分子（chiral molecules）的方法对有机合成与药物化学至关重要。本数据集收录了手性醇与手性胺合成相关的研究工作。我们通过易得酮酸/酯（keto acids/esters）的一锅法不对称还原胺化（asymmetric reductive amination）/环化序列，建立了具有广泛适用性的对映体富集NH内酰胺（enantioenriched NH lactams）合成方法。此外，我们还实现了一种高效简洁的策略，通过钌催化的直接不对称还原胺化合成对映体富集的N-未保护α-氨基缩醛（N-unprotected α-amino acetals）。另外，我们在温和条件下开发了环状α,β-不饱和酮（cyclic α, β-unsaturated ketones）的不对称1,2-还原反应，以原位生成的、与(R)-DTBM-C3*-TunePhos配体结合的氢化铜（copper hydride）为催化剂，获得了多种对映体富集的环状烯丙醇（enantiomerically enriched cyclic allylic alcohols）。