Characterization of behavior profile and social competence of individuals with the del22q11.2 syndrome

Abstract:PURPOSE:to characterize the behavioral problems and social competence of individuals with del22q11.2 syndrome and compare them with typically developing individuals, according to information from parents.METHODS:participated in this study 24 parents of individuals of both sexes between 6 and 18 years, being 12 individuals with the syndrome del22q11.2 (sample group) and 12 individuals with typically developing (control group). The behavioral inventory "Child Behavior Checklist (CBCL)" was applied.RESULTS:eight of the twelve patients with the syndrome were classified as "clinical" as the scales of behavior and Internalizing Problems. Five of the twelve individuals of sample group were "clinical" as the scales of behavior and Externalizing Problems. The skills of social competence, ten of the twelve individuals sample group were "clinical".CONCLUSION:individuals with the diagnostic of the del22q11.2 syndrome, according with opinion their parents present behavioral and social problems in different degrees of commitment. Comparing the groups, was observed statistically significant differences in variables of externalizing and internalizing behaviors. Therefore, we conclude that the sample group presents more abnormal behavior compared to the control group.

摘要：
目的：本研究旨在基于家长提供的评估信息，表征del22q11.2缺失综合征（del22q11.2 syndrome）患者的行为问题与社交能力，并与正常发育个体进行对比。
方法：本研究共纳入24名6至18岁男女个体的家长，其中12名确诊del22q11.2缺失综合征的个体为病例组，12名正常发育个体为对照组。研究采用儿童行为量表（Child Behavior Checklist, CBCL）开展评估。
结果：12名综合征患者中，有8名在行为量表及内化问题（Internalizing Problems）维度上被归类为临床异常；12名病例组个体中有5名在行为量表及外化问题（Externalizing Problems）维度上被归类为临床异常。在社交能力维度上，12名病例组个体中有10名被归类为临床异常。
结论：基于家长的反馈，确诊del22q11.2缺失综合征的个体存在不同程度的行为与社交问题。组间对比显示，外化行为与内化行为维度的变量存在统计学显著性差异。综上，病例组的异常行为表现显著多于对照组。