Inhibition of histone readers bromodomain extra-terminal proteins alleviates scleroderma fibrosis

We assessed transcriptomic changes in fibroblasts isolated from skin biopsies from diffuse cutaneous scleroderma patients before and after BET inhibitor JQ1 treatment RNA-seq analysis of fibroblasts in diffuse cutaneous systemic sclerosis patients after JQ1 treatment

本研究对弥漫性皮肤型硬皮病（diffuse cutaneous scleroderma）患者皮肤活检分离的成纤维细胞（fibroblasts）经BET抑制剂JQ1处理前后的转录组变化进行了评估，并针对经JQ1处理后的弥漫性皮肤型系统性硬化症（diffuse cutaneous systemic sclerosis）患者的成纤维细胞开展了RNA测序（RNA-seq）分析。