Periodontal Inflammation Triggers a Site Specific and Wide Radius of Calcium Metabolic Effects on Alveolar Bone

This data was used in the study by Kuraji et al (2020). <br>Briefly, in this study, we used ⁴⁵Ca as an index of bone turnover and demonstrated for the first time that a unique site-specific nature of calcium metabolism occurs in alveolar bone during progression of ligature-induced periodontitis. During periodontitis, ⁴⁵Ca levels in the alveolar bone exhibited biphasic alterations, namely decreases and increases. In addition, ⁴⁵Ca uptake was suppressed at the alveolar crest close to the site of periodontal inflammation but enhanced in deep zones of the alveolar bone and furcation areas, which were distant from the site of ligation. <br>

本数据集应用于Kuraji等人2020年的研究工作。简要而言，该研究以钙-45（⁴⁵Ca）作为骨转换（bone turnover）的检测指标，首次证实：在结扎诱导性牙周炎（ligature-induced periodontitis）的病程进展中，牙槽骨（alveolar bone）的钙代谢存在独特的位点特异性特征。在牙周炎进程中，牙槽骨内的钙-45水平呈现双相动态变化，即表现为含量下降与上升的交替波动。此外，紧邻牙周炎症位点的牙槽嵴（alveolar crest）区域，钙-45的摄取受到抑制；而远离结扎位点的牙槽骨深层区域及根分叉区（furcation areas），钙-45的摄取则显著增强。