Phase III Study of Adriamycin/Taxotere Versus Adriamycin/Cytoxan for the Adjuvant Treatment of Node Positive or High Risk Node Negative Breast Cancer

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which combination chemotherapy regimen is more effective for breast cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of two combination chemotherapy regimens in treating women with breast cancer who have undergone surgery to remove the tumor.

研究背景：化疗药物通过不同作用机制阻止肿瘤细胞分裂，使其停止增殖或发生死亡。联合使用多种化疗药物可杀灭更多的肿瘤细胞。目前尚不明确哪种联合化疗方案对乳腺癌的治疗更为有效。
研究目的：本研究为一项随机Ⅲ期临床试验，旨在对比两种联合化疗方案在已接受肿瘤切除手术的女性乳腺癌患者中的治疗有效性。