Determinants of non-suppression HIV Viral Load among Children Receiving Antiretroviral Therapy in Simiyu Region: A Cross-Sectional Study Dataset.

The introduction of antiretroviral therapy (ART) with increasing access to effective human immunodeficiency virus (HIV) prevention, diagnosis, treatment, and care, including opportunistic infections, has significantly changed the natural course of HIV infection in adults and children. Viral load suppression (VLS) is an essential parameter of a therapy’s effectiveness after ART initiation as a surrogate marker for disease progression. However, despite substantial ART coverage in individuals with HIV in Tanzania, VLS among HIV-positive children receiving ART remains intolerably low at 18%, indicating that 82% of those enrolled in care and treatment centers receiving ART did not achieve VLS. Therefore, this data was collected and analyzed to determine factors affecting VLS in children with HIV infection receiving ART. The findings of this study will help us fill the knowledge gap on factors contributing to low VLS among children with HIV infection in Tanzania. In this database, we found that age at ART initiation and medication adherence play a significant role in VLS. HIV/AIDS programs should incorporate intensive interventions targeting early ART initiation for children and intensifying treatment adherence.

抗逆转录病毒疗法（antiretroviral therapy, ART）的推广，配合有效人类免疫缺陷病毒（human immunodeficiency virus, HIV）预防、诊断、治疗及包括机会性感染在内的照护服务可及性的持续提升，已极大改变了成人与儿童HIV感染的自然病程。病毒载量抑制（viral load suppression, VLS）是抗逆转录病毒治疗启动后评估疗法有效性的核心指标，可作为疾病进展的替代标志物。然而，尽管坦桑尼亚HIV感染者的抗逆转录病毒疗法覆盖已相当可观，但接受ART的HIV阳性儿童的VLS率仅为18%，处于令人难以接受的低位，这意味着在照护与治疗中心入组并接受ART的儿童中，有82%未实现病毒载量抑制。因此，本研究收集并分析相关数据，旨在明确接受ART的HIV感染儿童中影响VLS的相关因素。本研究结果将有助于填补坦桑尼亚HIV感染儿童VLS率偏低相关影响因素的认知空白。本数据库显示，ART启动时的年龄与用药依从性对VLS具有显著影响。HIV/AIDS相关项目应纳入针对性的强化干预措施，包括推动儿童尽早启动ART以及强化治疗依从性管理。