AMED CRE Consortium: Carbapenem-resistant Enterobacteriaceae in Asia

Carbapenem-resistant Enterobacteriaceae (CRE) are spreading throughout the world. The resistant organisms are already endemic in many Asian countries. Through support from AMED, we sequenced the genomes of CRE isolated in Asian countries, providing the basis for understanding the epidemiology of CRE and their resistance mechanisms. This information may contribute to the establishment of preventive measures, and to the development of novel drugs and detection/diagnostic systems for CRE infections.

碳青霉烯类耐药肠杆菌科（Carbapenem-resistant Enterobacteriaceae, CRE）正在全球范围内传播，这类耐药菌已在诸多亚洲国家呈地方性流行态势。在AMED的资助下，我们对在亚洲国家分离得到的CRE菌株完成了全基因组测序，为解析CRE的流行病学特征及其耐药机制提供了核心研究基础。相关研究成果可为CRE感染防控策略的制定、新型治疗药物的研发以及CRE感染检测与诊断系统的开发提供关键支撑。