Profiling epididymal white adipose tissue (eWAT) from obese db/db and lean control db/+ mice

This program addresses the gene signature associated with the development of type 2 diabetes in the db/db mice. Specifically, which genes are differentially expressed in adipose tissue of the db/db mice compared to the control db/+ mice? The db/db mice eWAT profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the eWAT of db/db mice compared to the corresponding db/+ controls.本研究聚焦于db/db小鼠2型糖尿病发病相关的基因特征（gene signature）。具体而言，相较于对照db/+小鼠，db/db小鼠脂肪组织内哪些基因存在差异表达？本研究通过分析db/db小鼠附睾白色脂肪组织（epididymal white adipose tissue, eWAT）的谱分析数据，以选定的P值与倍数变化作为筛选标准，鉴定出相较于对应db/+对照小鼠，db/db小鼠附睾白色脂肪组织中上调与下调的差异表达基因。