Supplementary Material for: Longitudinal Analysis of Drusen Volume in Intermediate Age-Related Macular Degeneration Using Two Spectral-Domain Optical Coherence Tomography Scan Patterns

<b><i>Purpose:</i></b> To evaluate two different spectral-domain optical coherence tomography (SD-OCT) scan patterns in eyes with intermediate age-related macular degeneration (AMD) for the longitudinal assessment of drusen volume. <b><i>Methods:</i></b> The data of 38 eyes of 38 AMD patients (age 69.97 ± 6.08 years) were included. The longitudinal drusen volume over 4 years was analyzed by annual SD-OCT raster scanning (field size 20 × 15°). Two raster scan patterns (A/B) differed in the distance between neighboring B-scans (240 vs. 30 µm) and in the number of averaged frames (4 vs. 15). <b><i>Results:</i></b> The mean drusen volume at baseline was 0.213 ± 0.100 mm³ (pattern A) and 0.219 ± 0.103 mm³ (pattern B) (<i>p</i> = 0.937). Linear mixed-effect models showed no significant difference for the change within 4 years for both pattern A (<i>p</i> = 0.8) and pattern B (<i>p</i> = 0.8). <b><i>Conclusions:</i></b> The results indicate that the performance of interpolation algorithms may be sufficient to balance for less dense raster scanning with regard to quantification of longitudinal drusen volume, which can be used as a surrogate marker for AMD progression in future clinical trials.

<b><i>研究目的：</i></b> 评估两种不同的光谱域光学相干断层成像（spectral-domain optical coherence tomography, SD-OCT）扫描模式，用于对中间期年龄相关性黄斑变性（age-related macular degeneration, AMD）患者的眼部进行玻璃膜疣体积的纵向评估。<b><i>研究方法：</i></b> 本研究纳入38名AMD患者共38只患眼，患者年龄为69.97±6.08岁。通过每年一次的SD-OCT光栅扫描（视野范围20×15°），分析为期4年的纵向玻璃膜疣体积变化。两种光栅扫描模式（A、B）的差异在于相邻B扫描的间距（分别为240μm与30μm）以及平均帧数（分别为4帧与15帧）。<b><i>研究结果：</i></b> 模式A组的基线平均玻璃膜疣体积为0.213±0.100 mm³，模式B组为0.219±0.103 mm³（<i>p</i>=0.937）。线性混合效应模型显示，两组在4年内的体积变化均无显著统计学差异（模式A：<i>p</i>=0.8；模式B：<i>p</i>=0.8）。<b><i>研究结论：</i></b> 本研究结果表明，在纵向玻璃膜疣体积量化分析中，插值算法的性能足以弥补低密度光栅扫描的不足；该指标可作为未来临床试验中AMD病情进展的替代标志物。