An aniline-substituted bile salt analog protects both mice and hamsters from multiple Clostridioides difficile strains

Bile salt analogs prevented spore germination of various Clostridioides difficile strains in vitro. Mice exhibited heterogeneity of CDI signs severity among C. difficile isolates tested. Bile salt analogs protected mice from CDI signs caused by several C. difficile isolates. An aniline-substituted bile salt analog prevented CDI in both mice and hamsters.

胆汁盐类似物（bile salt analogs）在体外能够抑制多种艰难梭菌（Clostridioides difficile）菌株的芽孢萌发。受试艰难梭菌分离株所诱导的小鼠艰难梭菌感染（Clostridioides difficile infection，简称CDI）症状严重程度存在显著异质性。胆汁盐类似物可保护小鼠免受多种艰难梭菌分离株引发的CDI症状侵扰。一种苯胺取代型胆汁盐类似物可在小鼠与仓鼠模型中均有效预防CDI。