Novel Double [3 + 2 + 1] Heteroannulation for Forming Unprecedented Dipyrazolo-Fused 2,6-Naphthyridines

A novel four-component strategy for the efficient synthesis of unprecedented dipyrazolo-fused 2,6-naphthyridines through a double [3 + 2+1] heteroannulation has been described. The bond-forming efficiency, accessibility, and generality of this synthesis make it highly valuable to assemble tetra-heterocyclic scaffolds.

本研究报道了一种基于双重[3+2+1]杂环化反应的新型四组分合成策略，可高效构建前所未有的二吡唑稠合2,6-萘啶类化合物。该合成方法具备优异的成键效率、底物可及性与反应普适性，在四环杂环骨架的构建中具有极高应用价值。