Additional file 14 of Gene networks and transcriptional regulators associated with liver cancer development and progression

Additional file 14. Master regulator molecules of genes downregulated in GE2-hepatocellular carcinoma (HCC). Significantly down regulated genes in GE2-HCC (n=13) versus NT (n=17) samples with mean fold change (FC) ≤ -2 and false discovery rate (FDR) ≤ 0.05 were identified (Additional file 5) and used as an input gene list for bioinformatics analyses. Master regulator molecules in the signal transduction pathways, at a distance of up to 10 steps upstream of the dysregulated genes, were identified using the curated database of pathways and protein interactions TRANSPATH®.

附加文件14：GE2型肝细胞癌（hepatocellular carcinoma, HCC）下调基因的主调控分子。本研究在GE2-HCC组（n=13）与NT组（n=17）的样本中，筛选出平均折叠变化（fold change, FC）≤-2且错误发现率（false discovery rate, FDR）≤0.05的显著下调基因（附加文件5），并将其作为输入基因列表用于生物信息学分析。借助经人工注释的通路与蛋白质相互作用数据库TRANSPATH®，本研究鉴定得到失调基因上游至多10步信号转导通路中的主调控分子。