TPO antibodies, thyroiditis and serum T4 in Hi-expressor transgenics, Lo-expressor transgenics and WT mice.

The data are shown graphically in Fig. 3. Values are the Mean ± SEM (5–7 mice) in sera drawn after 32 and 74 days (euthanasia). The upper limit (mean+2 SEM) for wild-type mice immunized with control-adenovirus (n = 4) are:- TPO Ab 15 Geo mean; Thyroiditis, 0.1%; T4, 4.3 µg/dL. Statistically significant differences are shown in Fig. 3. Bold indicates positive values; italics indicate decreased serum T4. None*: data for mice immunized 3× with A-sub-Ad are repeated to facilitate comparison with mice primed with CFA/Tg and CFA/PBS.

数据以图形形式呈现于图3中。所有数值为均值±标准误（Standard Error of the Mean, SEM），样本为5~7只小鼠，血清采集自免疫后32天及74天（安乐处死时）。经对照腺病毒免疫的野生型小鼠（n=4）的上限值（均值+2倍标准误）分别为：甲状腺过氧化物酶抗体（Thyroid Peroxidase Antibody, TPO Ab）15几何均值；甲状腺炎发生率0.1%；甲状腺素（Thyroxine, T4）4.3 µg/dL。图3中标注了具有统计学显著性的组间差异。加粗字体代表阳性检测结果，斜体字体代表血清T4水平降低。*注：为便于与经完全弗氏佐剂（Complete Freund's Adjuvant, CFA）+甲状腺球蛋白（Thyroglobulin, Tg）及CFA+磷酸盐缓冲液（Phosphate Buffered Saline, PBS）预免疫的小鼠进行对比，本部分重复展示了经3次免疫A-sub-Ad的小鼠数据。