Vitepyrroloids A–D, 2‑Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia

Vitepyrroloids A–D (1–4), four new 2-cyano-substituted pyrrole-ring-containing labdane diterpenoids, were isolated from the leaves of Vitex trifolia. Their structures were elucidated based on spectroscopic data analysis. The absolute configuration of compound 1 was determined by X-ray diffraction. Compounds 1–4 are unprecedented labdane diterpenoids featuring a 2-cyano-substituted pyrrole ring. Compound 1 showed cytotoxic activity against a human nasopharyngeal carcinoma cell line (CNE1) with an IC50 value of 8.7 μM.

Vitepyrroloids A–D（1–4）为4个全新的含2-氰基取代吡咯环的劳丹烷型二萜类化合物，均从蔓荆（Vitex trifolia）的叶片中分离得到。其结构通过光谱数据分析得以解析阐明，其中化合物1的绝对构型通过X射线衍射法确定。化合物1–4均为首次报道的带有2-氰基取代吡咯环的劳丹烷型二萜类化合物。化合物1对人鼻咽癌细胞系（CNE1）表现出细胞毒活性，半数抑制浓度（IC50）为8.7 μM。