Dataset_Recurrent_Intussusception_Jul25

<b><i></i></b>The purpose of this study was to assess the incidence of recurrent episodes of intussusception in children in southern and western India and identify risk factors associated with recurrence. This multicenter observational study was conducted from August 2019 to December 2022 in children with intussusception aged under 2 y admitted to 21 hospitals in four Indian states: Kerala and Karnataka in southern India and Maharashtra and Gujarat in western India. Clinical, epidemiological, and sociodemographic data were collected using structured questionnaires, medical records, and radiological reports. A single follow-up was conducted in July 2023 to assess vital status and the incidence of intussusception recurrence. Out of the 1406 children enrolled with intussusception, 85 were unavailable for follow-up, and 55 (4.2%) experienced one or more recurrent episodes during the study period. The median time to the first recurrence was 137 d. The incidence of recurrence was significantly higher in Kerala (40/697; 5.7%) than in the other three states (15/624; 2.4%; p = 0.027). Incessant crying and irritability were significantly more common in recurrent episodes (20/55; 36.4%) than in first episodes (289/1266; 22.8%; p = 0.008). Radiological reduction was significantly more common in recurrent cases (49/55; 89.1%) than in first episode cases (1037/1266; 78.5%; p = 0.039). This study reveals regional and clinical factors associated with recurrence of intussusception and highlights the need for region-specific protocols to optimize treatment and minimize the incidence of recurrence. The reasons for the regional disparities in the incidence of recurrence should be investigated.

本研究旨在评估印度南部及西部儿童肠套叠（intussusception）复发事件的发生率，并确定与复发相关的风险因素。这项多中心观察性研究（multicenter observational study）于2019年8月至2022年12月开展，研究对象为印度4个邦（南部的喀拉拉邦、卡纳塔克邦及西部的马哈拉施特拉邦、古吉拉特邦）21家医院收治的2岁以下肠套叠患儿。研究通过结构化问卷、病历记录及影像学报告收集临床、流行病学及社会人口学数据。2023年7月进行了一次随访，以评估患儿的生命状态及肠套叠复发率。在纳入研究的1406例肠套叠患儿中，85例失访，55例（4.2%）在研究期间发生一次或多次复发事件。首次复发的中位时间为137天。喀拉拉邦的复发率（40/697；5.7%）显著高于其他三个邦（15/624；2.4%；p=0.027）。复发事件中持续哭闹及易激惹的发生率（20/55；36.4%）显著高于首次发作（289/1266；22.8%；p=0.008）。复发病例中影像学复位（radiological reduction）的比例（49/55；89.1%）显著高于首次发作病例（1037/1266；78.5%；p=0.039）。本研究揭示了与肠套叠复发相关的地区及临床因素，强调需制定地区特异性方案以优化治疗并降低复发率。复发率地区差异的原因有待进一步研究。