Gold Meets Rhodium: Tandem One-Pot Synthesis of β‑Disubstituted Ketones via Meyer–Schuster Rearrangement and Asymmetric 1,4-Addition

An asymmetric one-pot tandem Au/Rh-catalyzed synthesis of highly enantioenriched β-disubstituted ketones starting from racemic propargyl alcohols is disclosed. The compatibility of the two metal complexes (Au/Rh) and their orthogonal ligand systems (NHC/diene) in this bimetallic catalytic system is investigated.

本文报道了以外消旋炔丙醇为起始原料，通过金/铑（Au/Rh）催化的不对称一锅法串联反应，合成高度对映富集的β-二取代酮的方法。本研究对该双金属催化体系中两种金属配合物（Au/Rh）及其正交配体体系（N-杂环卡宾(NHC)/二烯(diene)）的兼容性进行了考察。