Supplementary data for Shared Genetic Architecture and Causal Relationship between Serum 25-Hydroxyvitamin D and Bone Mineral Density.zip

Leveraging individual-level data from the UK Biobank (UKB) cohort and summary-level data from the genome-wide association studies(GWASs) conducted on European individuals for serum 25OHD (N = 417,580) and estimated heel BMD (eBMD, N = 426,824), we systematically elucidated the shared genetic architecture underlying serum 25OHD and eBMD through a comprehensive genome-wide cross-trait design.

本研究依托英国生物样本库（UK Biobank, UKB）队列的个体水平数据，以及针对欧洲人群开展的血清25羟维生素D（serum 25OHD，N=417,580）和估算跟骨骨密度（estimated heel BMD, eBMD，N=426,824）相关全基因组关联研究（Genome-Wide Association Studies, GWASs）的汇总水平数据，通过全面的全基因组跨性状研究设计，系统阐明了血清25羟维生素D与估算跟骨骨密度所共有的遗传结构。