Environmental variation partitioned into separate heritable components

Trait variation is normally separated into genetic and environmental components, yet genetic factors also control the expression of environmental variation, encompassing plasticity across environmental gradients and within-environment responses. We defined four components of environmental variation: plasticity across environments, variability in plasticity, variation within environments, and differences in within-environment variation across environments. We assessed these components for cold tolerance across five rearing temperatures using the Drosophila melanogaster Genetic Reference Panel (DGRP). The four components were found to be heritable, and genetically correlated to different extents. By whole genome single marker regression, we detected multiple candidate genes controlling the four components and showed limited overlap in genes affecting them. Using the binary UAS-GAL4 system, we functionally validated the effects of a subset of candidate genes affecting each of the four comp...

性状变异通常划分为遗传组分与环境组分，然而遗传因素亦调控环境变异的表达，涵盖跨环境梯度的可塑性及环境内响应。我们定义了环境变异的四个组分：跨环境可塑性、可塑性变异、环境内变异，以及跨环境的环境内变异差异。借助黑腹果蝇遗传参考面板（Drosophila melanogaster Genetic Reference Panel，DGRP），我们在五个饲养温度下评估了耐寒性的这些组分。研究发现，这四个组分均具有遗传性，且存在不同程度的遗传相关性。通过全基因组单标记回归分析，我们检测到多个调控这四个组分的候选基因，并证实影响这些组分的基因重叠度有限。利用二元UAS-GAL4系统，我们对影响这四个组分中每个组分的部分候选基因的效应进行了功能验证...